Evidence Informed

Sources

Review our Sources

At Lipedema Canada, we strive to inform our materials based on the latest scholarly research. With the guidance of our Medical Advisory Board, we aim to provide Canadians with trustworthy information about Lipedema.

Our colleges at The Lipedema Foundation maintain and exception resource of up to date articles for lipedema. Please visit this resource at Legato library.

Brochures

Sources for Clinicians and Patient Brochures

Donohoe, K. J., Carroll, B. J., Chung, D. K. V., Dibble, E. H., Diego, E., Giammarile, F., Grant, F. D., Lai, S. Y., Linden, H., Miller, M. E., Pandit-Taskar, N., Tawa, N. E., & Vidal-Sicart, S. (2023). Summary: Appropriate Use Criteria for Lymphoscintigraphy in Sentinel Node Mapping and Lymphedema/Lipedema. *Journal of Nuclear Medicine.* https://doi.org/10.2967/jnumed.123.265560

Tran, K., & Horton, J. (2022). Liposuction for Lipedema: 2022 Update. *Canadian Journal of Health Technologies, 2*(8), 21. https://www.canjhealthtechnol.ca/index.php/cjht/article/download/RC1447/838?inline=1

Ratliff, C. R., Yates, S., McNichol, L., & Gray, M. (2022). Compression for Lower Extremity Venous Disease and Lymphedema (CLEVDAL): Update of the VLU Algorithm. *Journal of Wound, Ostomy, and Continence Nursing: Official Publication of The Wound, Ostomy and Continence Nurses Society, 49*(4), 331–346. https://doi.org/10.1097/WON.0000000000000889

Lipedema Foundation. (2022). Lipedema Diagnosis Comparison Chart: A Summary of Commonly Used Guidelines (p. 2). Lipedema Foundation. https://lipedema.org/dx-comparison

Pannier, F., Noppeney, T., Alm, J., Breu, F. X., Bruning, G., Flessenkämper, I., Gerlach, H., Hartmann, K., Kahle, B., Kluess, H., Mendoza, E., Mühlberger, D., Mumme, A., Nüllen, H., Rass, K., Reich-Schupke, S., Stenger, D., Stücker, M., Schmedt, C. G., … Valesky, E. (2022). S2k guidelines: diagnosis and treatment of varicose veins. *Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete.* https://doi.org/10.1007/s00105-022-04977-8

Maldonado, A. A., Ramos, E., García-Alonso, P., Jover, J. J., Holguín, P., Fernández-Cañamaque, J. L., & Cristóbal, L. (2021). [Multidisciplinary approach in the lymphedema patient: From rehabilitation to microsurgery]. *Rehabilitacion.* https://doi.org/10.1016/j.rh.2021.06.003

Herbst, K. L., Kahn, L. A., Iker, E., Ehrlich, C., Wright, T., McHutchison, L., Schwartz, J., Sleigh, M., Donahue, P. M., Lisson, K. H., Faris, T., Miller, J., Lontok, E., Schwartz, M. S., Dean, S. M., Bartholomew, J. R., Armour, P., Correa-Perez, M., Pennings, N., … Larson, E. (2021). Standard of care for lipedema in the United States. *Phlebology.* https://doi.org/https://journals.sagepub.com/doi/10.1177/02683555211015887

Vignes, S., Albuisson, J., Champion, L., Constans, J., Tauveron, V., Malloizel, J., Quéré, I., Simon, L., Arrault, M., Trévidic, P., Azria, P., & Maruani, A. (2021). Primary lymphedema French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins). *Orphanet Journal of Rare Diseases, 16.* https://doi.org/10.1186/s13023-020-01652-w

Creager Mark A., Hamburg Naomi M., Calligaro Keith D., Casanegra Ana I., Freeman Rosario, Gordon Phyllis A., Gornik Heather L., Kim Esther S.H., Leeper Nicholas J., Merli Geno J., Niazi Khusrow, Olin Jeffrey W., Quiroz Rene, Rrapo Kaso Elona, Wasan Suman, Waxler Andrew R., White Christopher J., White Solaru Khendi, & Williams Marlene S. (2021). 2021 ACC/AHA/SVM/ACP Advanced Training Statement on Vascular Medicine (Revision of the 2004 ACC/ACP/SCAI/SVMB/SVS Clinical Competence Statement on Vascular Medicine and Catheter-Based Peripheral Vascular Interventions). *Circulation: Cardiovascular Interventions, 0*(0), HCV.0000000000000079. https://doi.org/10.1161/HCV.0000000000000079

Peros, I., & Lillis, P. (2021). Noncosmetic applications of liposuction. *Dermatological Reviews, 2*(4), 220–223. https://doi.org/https://doi.org/10.1002/der2.86

Forner Cordero, I., López Martin, M., Reina Gutiérrez, L., Belmonte, R., Ruiz Miñarro, R., Crespo Cobo, M. P., Pardo Sievers, B., Pujol Blaya, V., De Miguel Benadiba, C., & Puigdellivol, C. (2020). [Management of patients with lymphatic diseases and lipoedema during the COVID-19 pandemic. Recommendations of the Spanish Group of Lymphology]. *Rehabilitacion.* https://doi.org/10.1016/j.rh.2020.07.003

Sandhofer, M., Hanke, C. W., Habbema, L., Podda, M., Rapprich, S., Schmeller, W., Herbst, K., Anderhuber, F., Pilsl, U., Sattler, G., Sandhofer, M., Moosbauer, W., Sattler, S., Schauer, P., Faulhaber, J., Maier, S., Barsch, M., Mindt, S., & Halk, A. B. (2020). Prevention of Progression of Lipedema With Liposuction Using Tumescent Local Anesthesia: Results of an International Consensus Conference. *Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.], 46*(2),

Website Content

Wesbite Content Sources

Amato, A. C., Amato, J. L., Benitti, D., Amato, A. C., Amato, J. L., & Benitti, D. (2024). Efficacy of Liposuction in the Treatment of Lipedema: A Meta-Analysis. *Cureus, 16*(2). https://doi.org/10.7759/cureus.55260

Corrêa, A. C. A., Barbosa, R. P., Souza, M. A. e, Prado, A. L. C. do, Siqueira, E. de F., Silva, G. C., Silva, G. L. da, Souza, R. B., Inácio, J. P., Filho, P. R. N., Júnior, J. U. M. C., & Porto, J. D. S. (2023). Lipedema e caracteristicas relevantes: revisão de literatura. *Brazilian Journal of Health Review, 6*(6), 30748–30761. https://doi.org/10.34119/bjhrv6n6-317

Bonetti, G., Dhuli, K., Kaftalli, J., Micheletti, C., Donato, K., Michelini, S., Ricci, M., Cestari, M., Fulcheri, E., Michelini, S., Herbst, K. L., Marceddu, G., & Bertelli, M. (2023). Characterization of somatic mutations in the pathogenesis of lipedema. *La Clinica Terapeutica, 174*(Suppl 2(6)), 249–255. https://doi.org/10.7417/CT.2023.2495

Verde, L., Camajani, E., Annunziata, G., Sojat, A., Marina, L. V., Colao, A., Caprio, M., Muscogiuri, G., & Barrea, L. (2023). Ketogenic Diet: A Nutritional Therapeutic Tool for Lipedema? *Current Obesity Reports.* https://doi.org/10.1007/s13679-023-00536-x

Suarez, A. C., Hammel, J. H., & Munson, J. M. (2023). Modeling lymphangiogenesis: Pairing in vitro and in vivo metrics. *Microcirculation (New York, N.Y.: 1994).* https://doi.org/10.1111/micc.12802

Yoon, H., & Park, T.-E. (2023). Engineered adipose tissue platforms: recent breakthroughs and future perspectives. *Organoid, 3,* e1. https://doi.org/10.51335/organoid.2023.3.e1

Ernst, A. M., Bauer, H., Bauer, H.-C., Steiner, M., Malfertheiner, A., & Lipp, A.-T. (2023). Lipedema Research—Quo Vadis? *Journal of Personalized Medicine, 13*(1), 98. https://doi.org/10.3390/jpm13010098

Kloosterman, L. M., Hendrickx, A., Scafoglieri, A., Jager-Wittenaar, H., & Dekker, R. (2023). Functioning of People with Lipoedema According to All Domains of the International Classification of Functioning, Disability and Health: A Scoping Review. *International Journal of Environmental Research and Public Health, 20*(3), 1989. https://doi.org/10.3390/ijerph20031989

Singhal, D., Börner, K., Chaikof, E. L., Detmar, M., Hollmén, M., Iliff, J. J., Itkin, M., Makinen, T., Oliver, G., Padera, T. P., Quardokus, E. M., Radtke, A. J., Suami, H., Weber, G. M., Rovira, I. I., Muratoglu, S. C., & Galis, Z. S. (2023). Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium. *Frontiers in Physiology, 14,* 1099403. https://doi.org/10.3389/fphys.2023.1099403

Stücker, M., Protz, K., Eder, S., Läuchli, S., Traber, J., & Dissemond, J. (2022). [Diagnosis of leg edema]. *Dermatologie (Heidelberg, Germany).* https://doi.org/10.1007/s00105-022-05082-6

Donohoe, K. J., Carroll, B. J., Chung, D. K., Dibble, E. H., Diego, E., Giammarile, F., Grant, F. D., Lai, S. Y., Linden, H., Miller, M. E., Pandit-Taskar, N., Tawa, N. E., Jr, & Vidal-Sicart, S. (2022). Appropriate Use Criteria for Lymphoscintigraphy 9_8_22 Final BOD Approval.pdf. *Society of Nuclear Medicine and Molecular Imaging.

Poojari, A., Dev, K., & Rabiee, A. (2022). Lipedema: Insights into Morphology, Pathophysiology, and Challenges. *Biomedicines, 10*(12), 3081. https://doi.org/10.3390/biomedicines10123081

Lipedema Foundation. (2022). Lipedema Diagnosis Comparison Chart: A Summary of Commonly Used Guidelines (p. 2). Lipedema Foundation. https://lipedema.org/dx-comparison

Alcolea, J., Alonso, Á. B., Arroyo, B. A., Domingo, P., Galindo, G. A., Gracia, G. M., Iglesias, U. C., Insua, N. E., Martín, C. E., Martínez, Á. J., Ovoa, R. M., Río-González, Á., & Villarino, M. A. (2018). Documento de Consenso Lipedema: Consensus document on Lipedema (p. 90). Spanish Association of Lymphedema and Lipedema (AEL). https://aelinfedema.org/wp-content/uploads/2018/03/Consenso-Lipedema-2018.pdf

Wounds UK. (2017). Best Practice Guidelines: The Management of Lipoedema. Wounds UK. https://www.lipoedema.co.uk/wp-content/uploads/2017/05/WUK_Lipoedema-BPS_Web.pdf

037-012 S1-Leitlinie Lipödem (Clinical Guidelines AWMF Registernummer 037-012; p. 27). (2015). AWMF (A rarbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachverbindungen eV). https://www.awmf.org/uploads/tx_szleitlinien/037-012l_S1_Lipoedem_2016-01-abgelaufen.pdf

Damstra, R. J., Habbema, L., Hendrickx, A., Feenstra, C., Kemperman, P., Verhoeff-Braat, C., van der Vleuten, C., Voesten, H., Smidt, T., de Haas, M., van Everdingen, J., Halk, A., & Urgert, M. (2014). Lipedema Guidelines in the Netherlands 2014. Dutch Society for Dermatology and Venereology. https://www.gdlymph.eu/assets/pdf/Dutch-lipoedema-guideline-2014.pdf

Disclaimer: Lipedema Canada is not a medical provider. This guide is for informational purposes only and is not intended to substitute for professional medical advice, diagnosis, or treatment. Seek the advice of your physician regarding a medical condition or treatment before undertaking any new healthcare regimen.